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The Italian National Health System (SSN) has pioneered a proactive remote monitoring model that replaces traditional "passive surveillance." In 2026, Italian patients on Direct Oral Anticoagulants (DOACs) are increasingly managed via AI-supported mobile platforms.

These systems analyze real-time data to identify high-risk patterns—such as a subtle decline in kidney function (GFR) or a drop in hemoglobin—long before physical symptoms appear. By shifting from scheduled check-ups to predictive alerts, Italian clinics have significantly reduced emergency hospitalizations for occult bleeding and stroke among the elderly.